Publications

Kulick, D., Moon, E., Riffe, R.M., Teicher, G., Van Deursen, S., Person, A., He, W., Aaron, G., Downes, G.B., Devoto, S., O’Neil, A (2022). Amyotrophic Lateral Sclerosis-Associated Persistent Organic Pollutant cis-Chlordane Causes GABAA-Independent Toxicity to Motor Neurons, Providing Evidence toward an Environmental Component of Sporadic Amyotrophic Lateral Sclerosis. ACS Chemical Neuroscience. 13: 3567-3577.

Barnaby, W., Dorman Barclay, H.E., Nagarkar, A., Perkins, M., Teicher, G., Trapani, J.G., and Downes, G.B. (2022) GABAA alpha Subunit Control of Hyperactive Behavior in Developing Zebrafish. Genetics. iyac011.

Sant, K.E., Annunziato, K., Conlin, S., Teicher, G., Chen, P., Venezia, O., Downes, G.B., Park, Y., and Timme-Laragy, A.R. (2020) Developmental exposures to perfluooctanesulfonic Acid (PFOS) impacts embryonic nutrition, pancreatic morphology, and adiposity in the zebrafish (Danio rerio). Environmental Pollution 275: 116644.

Yildiz, O., Downes, G.B., Sagerstrom, C.G. (2019) Zebrafish prdm12b acts independently of nkx6.1 repression to promote eng1b expression in the neural tube p1 domain. Neural Development 14: 5.

Monesson-Olson B., McClain J.J., Case A.E., Dorman H.E., Turkewitz D.R., Steiner A.B., Downes G.B. (2018) Expression of the eight GABAA receptor alpha subunits in the developing zebrafish central nervous system. PLoS ONE 13: e0196083

Mott M., Luna V.M., Park J.Y., Downes G.B, Epley K., Ono F. (2017) Expressing acetylcholine receptors after innervation suppresses spontaneous vesicle release and causes muscle fatigue. Scientific Reports 7:1674

Johnson, K., Barragan, J., Bashiruddin, S., Smith, C.J., Tyrrell, C., Parsons, M.J., Doris, R., Kucenas, S., Downes, G.B., Velez, C.M., Schneider, C., Sakai, C., Pathank, N., Anderson, K., Stein, R., Devoto, S.H., Mumm, J.S., and Barresi, M.J. (2016) Gfap-positive radial glial cells are an essential progenitor population for later-born neurons and glia in the zebrafish spinal cord. Glia 64: 1170-89

Zannino, D.A., Downes, G.B., and Sagerstrom, C.G. (2014) prdm12 specifies the p1 progenitor domain and reveals a role for V1 interneurons in swim movements. Developmental Biology 390: 247-60.

de Soysa, Y.T., Ulrich, A., Friedrich, T., Pite, D., Compton, S., Ok, D., Bernardos, R.L., Hsieh, S., Downes, G.B., Rachael Stein, Lagdameo, M.C., Halvorsen, K., and Barresi, M.J.F. (2012) Macondo crude oil from the Deepwater Horizon oil spill disrupts specific developmental processes during zebrafish embryogenesis. BMC Biology 10: 40.

Khan, T.M., Benaich, N., Malone, C.F., Bernandos, R.L., Russell, A.R., Downes, G.B., Barresi, M.J., and Hutson, L.D. (2012) Vincrisitne and bortezomib cause axon outgrowth and behavioral defects in larval zebrafish. Journal of the Peripheral Nervous System 17: 76-89.

McKeown, K.A., Moreno, R., Hall, V.L., Ribera, A.B., and Downes, G.B. (2012) Disruption of Eaat2b, a glutamate transporter, results in abnormal motor behaviors in developing zebrafish. Developmental Biology.

Friedrich, T., Lambert, A.M., Masino, M.A., Downes, G.B. (2012) Mutation of zebrafish dihydrolipoamide branched-chain transacylase E2 results in motor dysfunction and models maple syrup urine disease. Disease Models and Mechanisms.

Olson, B.D., Sgourdou, P., and Downes, G.B. (2010) Analysis of a zebrafish behavioral mutant reveals a dominant mutation in atp2a1/SERCA1. Genesis 48: 354-61.

McKeown, K.A., Downes, G.B., and Hutson, L.D. (2009) Modular labatory exercises to analyze the development of zebrafish motor behavior. Zebrafish 6: 179-85.

Downes, G.B. and Granato, M. (2006). Supraspinal input is not required to generate glycine-mediated locomotive behaviors in the zebrafish embryo. J. Neurobiology 66: 437-51.

Hiromi, H., Saint-Amant, L., Downes, G.B., Cui, W.W., Zhou, W., Granato, M., Kuwada, J.Y. (2005). Zebrafish bandoneon mutants display behavioral defects due to a mutation in the glycine receptor beta subunit. P.N.A.S. 102: 8345-50.

Downes, G.B. and Granato, M. (2004). Acetylcholinesterase function is dispensable for neurite growth but is critical for neuromuscular synapse stability. Developmental Biology 270: 232-245.

Downes, G.B., Waterbury, J.A., and Granato, M. (2002). Rapid in vivo labeling of identified zebrafish neurons. Genesis 34: 196-202.

Downes, G.B., Gilbert,  D.J., Copeland, N.G., Gautam, N. and Jenkins, N.A.*  (1999).  Chromosomal mapping of five mouse G protein γ subunits.  Genomics 57: 173-6.

Downes, G.B and Gautam, N.(1999) The G protein subunit gene families. Genomics 62: 447-55.

Downes, G.B., Copeland, N., Jenkins, N.A., and Gautam, N. (1998). Structure And mapping of the G protein gamma3 subunit gene and a divergently transcribed novel gene, Gng3lg. Genomics 15: 220-30.

Gautam, N.,  Downes, G.B., Yan, K., and Kisselev, O. (1998). The G protein βγ complex.  Cell Signal. 10: 447-55.